Free fatty acids, central nervous system and bromazepam.

The concentrations of free fatty acids in plasma were estimated in thirty-three subjects, before and after (24 hours and 72 hours) the start of bromazepam oral administration in a daily dose of 6 mg (1.5 mg at 7 a.m., 1.5 mg at 3 p.m. and 3 mg at 11 p.m.). A fourth estimation was performed 72 hours after drug discontinuation. A control group of twelve subjects received a placebo according to the same dosage pattern. In comparison with the first estimation, the subsequent free fatty acid values showed a significant decrease (p less than 0.05, p less than 0.05 and p less than 0.001, respectively), whereas the control group showed no significant decrease (p greater than 0.05). The aim of the present article is to present the results of the three day-standard oral administration of bromazepam on free fatty acid concentration of plasma. All the samples, including the control group, were taken from a population free from any disease affecting adipose tissue metabolism.